Various human nervous system diseases, such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, Huntington’s, and Parkinson’s diseases, are associated with the same basic disorder: the loss of nerve cells capacity to fold their proteins correctly, which causes protein aggregations that form "clumps" that end up generating the cell death (Figure 1). If folded properly a protein or a paper plane can accomplish their respective functions, catalyze a reactions, in the case of some proteins and fly in the case of the plane. Incorrect folding cause that proteins lose their normal functions and causes protein aggregations that form "clumps" that end up generating the cell death. Analogously, a paper plane incorrectly folded would not be able to flight and se hara bola con otros defective paper planes. With this example we can explain better, the conformation or shapes of the proteins.